Somatic gene copy number alterations in colorectal cancer: new quest for cancer drivers and biomarkers.
作者： H Wang , L Liang , J-Y Fang , J Xu
DOI: 10.1038/ONC.2015.304
关键词: Colorectal cancer 、 Copy-number variation 、 Biology 、 Bioinformatics 、 Somatic cell 、 Personalized treatment 、 Cancer research 、 Colorectal carcinogenesis 、 Functional genes 、 Gene
摘要: Colorectal cancer (CRC) results from the accumulation of genetic alterations, and somatic copy number alterations (CNAs) are crucial for development CRC. Genome-wide survey CNAs provides opportunities identifying driver genes in an unbiased manner. The detection aberrant may provide novel markers early diagnosis personalized treatment A major challenge array-based profiling is to distinguish that play causative roles random accumulate during colorectal carcinogenesis. In this view, we systematically discuss frequent CRC, focusing on functional have potential diagnostic, prognostic therapeutic significance.
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