Identification of a characteristic copy number alteration profile by high-resolution single nucleotide polymorphism arrays associated with metastatic sporadic colorectal cancer.

摘要: BACKGROUND Metastatic dissemination is the most frequent cause of death in patients with sporadic colorectal cancer (sCRC). It believed that metastatic process related at least part to a specific background genetic alterations accumulated cells from primary tumors, and ability detect such critical for identification sCRC who are risk developing metastases. METHODS The authors used high-resolution, 500-K single nucleotide polymorphism arrays identify copy number alteration profiles present diagnosis tumors (n = 23) versus nonmetastatic (n = 26) sCRC. RESULTS The results revealed characteristic pattern involved losses 23 regions chromosomes 1p, 17p, 18q, together gains 35 7 13q. CONCLUSIONS In line expectations, profile investigated multiple genes were associated previously (ie, SMAD2) and/or podocalyxin-like [PODXL]), it also was poorer outcome. Cancer 2014;120:1948–1959. © 2014 American Society.