Emerging paradigms in the treatment of liver metastases in colorectal cancer

摘要: Efforts to combat colorectal cancer have benefited from improved screening and surveillance, which facilitates early detection. The survival rate associated with diagnosis at stage I is approximately 90%. However, progress in improving metastatic (mCRC) has been minimal. This review focuses on mCRC special emphasis the molecular aspects of liver metastases, one most frequently involved organ site. Better evidence required guide decisions for surgical other interventions used clinical management mCRC. Results different treatment modalities exposed significant gaps existing paradigms management. Indeed there a critical need better understand events pathways that lead metastasis. Such focused approach may help identify biomarkers drug targets can be useful applications. With this focus, we provide an account spread CRC liver. Specifically, changes DNA RNA levels are metastases discussed. Similarly, describe relevant microRNAs identified as regulators gene expression also serve biomarkers. Conventionally applied not yet specific sensitive enough relied routine decision making. Hence search novel critically needed especially if these utilized using liquid biopsies. provides comprehensive analysis current along potential future directions could reshape diagnostic thus mitigate devastating impact metastasis