Colorectal Cancer Biomarkers: Where Are We Now?
作者： Maria Gonzalez-Pons , Marcia Cruz-Correa
DOI: 10.1155/2015/149014
关键词: Oncology 、 Mortality rate 、 Incidence (epidemiology) 、 Colorectal cancer 、 Gastroenterology 、 Medicine 、 Chemotherapy 、 Molecular Diagnostic Method 、 Asymptomatic 、 microRNA 、 Internal medicine 、 Colonoscopy
摘要: Colorectal cancer is one of the major causes cancer-related death in Western world. Patient survival highly dependent on tumor stage at time diagnosis. Reduced sensitivity to chemotherapy still a obstacle effective treatment advanced disease. Due fact that colorectal mostly asymptomatic until it progresses stages, implementation screening programs aimed early detection essential reduce incidence and mortality rates. Current diagnostic methods range from semi-invasive procedures such as colonoscopy noninvasive stool-based tests. The combination absence symptoms, nature currently used methods, suboptimal accuracy fecal blood tests results diagnosis stages significant number individuals. Alterations gene expression leading carcinogenesis are reflected dysregulated levels nucleic acids proteins, which can be for development novel, minimally invasive molecular biomarkers. purpose this review discuss commercially available well highlight some new candidate predictive prognostic markers tumor, stool, samples.
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Peter Beighton, Greta Beighton, de la Chapelle, A. The Person Behind the Syndrome. pp. 209- 209 ,(1997) , 10.1007/978-1-4471-0925-9_118
S. J. Winawer, R. W. Burt, P. Rozen, D. T. Bishop, H. T. Lynch, Risk and surveillance of individuals with heritable factors for colorectal cancer. WHO Collaborating Centre for the Prevention of Colorectal Cancer. Bulletin of The World Health Organization. ,vol. 68, pp. 655- 665 ,(1990)
Poul Erik Petersen, The burden of oral disease: challenges to improving oral health in the 21st century. Bulletin of The World Health Organization. ,vol. 83, pp. 3- 3 ,(2005) , 10.1590/S0042-96862005000100003
Dmitry Kislitsin, Aaron Lerner, Gad Rennert, Zeev Lev, K-ras mutations in sporadic colorectal tumors in Israel: unusual high frequency of codon 13 mutations and evidence for nonhomogeneous representation of mutation subtypes. Digestive Diseases and Sciences. ,vol. 47, pp. 1073- 1079 ,(2002) , 10.1023/A:1015090124153
R Jover, A Castells, X Llor, M Andreu, Predictive value of microsatellite instability for benefit from adjuvant fluorouracil chemotherapy in colorectal cancer. Gut. ,vol. 55, pp. 1819- 1820 ,(2006) , 10.1136/GUT.2006.105627
Lauri A. Aaltonen, Bert Vogelstein, Jukka Pekka Mecklin, Kenneth W. Kinzler, Jeremy R. Jass, Patrice Watson, Henry T. Lynch, Stanley R. Hamilton, Päivi Peltomäki, Pertti Sistonen, Matti Juhola, Albert de la Chapelle, Jane S. Green, Gustav Tallqvist, Heikki Järvinen, Replication Errors in Benign and Malignant Tumors from Hereditary Nonpolyposis Colorectal Cancer Patients Cancer Research. ,vol. 54, pp. 1645- 1648 ,(1994)
G. I Meling, P Laurent-Puig, B. J Iacopetta, R Glaesener, O. P. F Clausen, F Al-Mulla, W Giaretti, V. J Bubb, A. F. P. M de Goeij, G Gaudernack, T Ohkusa, P Quirke, A Rapallo, N Hawkins, R Rosell, T. O Rognum, S. N Andersen, R Smith, J Costa, R Ward, I Hoffmann, T Fujimori, D Cunningham, D Morton, C. T Croke, J Oates, X. F Sun, S Bell, P. A Clarke, S. T Wang, J Breivik, O Muller, A. R Norman, J. W Arends, M Pauly, D Dillon, H. J. N Andreyev, S. D Finkelstein, A. J Senagore, C. N Hall, K Wilkinson, N Lees, N. R Cruickshank, H. S Goh, D Snary, E Jullian, C Valavanis, L Losi, A Russo, H. M Rabes, J Piris, S Wadler, Y Ono, T Azuma, A Font, C Zietz, M Beranek, J. C Fox, S. A Halter, R Benamouzig, B. R Dix, H Zhang, C Faber, K Omura, V. E Pricolo, C Troungos, K Krtolica, J Benhattar, J. W. C Ho, N. Urosevic, T Lovig, D. P O'Donoghue, J. S Thebo, P De Angelis, J. Q Lee, J Young, Bazan, P Jandik, S Olschwang, S. T Yuen, T Walsh, S Malik, M Tanaka, Kirsten ras mutations in patients with colorectal cancer : the ‘RASCAL II’ study Faculty of Health; Institute of Health and Biomedical Innovation. ,vol. 85, pp. 692- 696 ,(2001)
Won-Seok Jo, John M. Carethers, Chemotherapeutic implications in microsatellite unstable colorectal cancer Cancer Biomarkers. ,vol. 2, pp. 51- 60 ,(2006) , 10.3233/CBM-2006-21-206
Fiona H Blackhall, Alastair Greystoke, Malcolm Ranson, Andrew Hughes, Lucy Knight, Ruth E Board, Caroline Dive, DNA methylation in circulating tumour DNA as a biomarker for cancer. Biomarker Insights. ,vol. 2, pp. 307- 319 ,(2007) , 10.4137/BMI.S0
Isao Miyashiro, Christine Kuo, Kelly Huynh, Aritoshi Iida, Donald Morton, Anton Bilchik, Armando Giuliano, Dave S B Hoon, Molecular Strategy for Detecting Metastatic Cancers with Use of Multiple Tumor-specific MAGE-A Genes Clinical Chemistry. ,vol. 47, pp. 505- 512 ,(2001) , 10.1093/CLINCHEM/47.3.505