Expression of EGFR, Her2 predict lymph node metastasis (LNM)-associated metastasis in colorectal cancer.

摘要: Background: As key molecules that drive progression and chemoresistance in gastrointestinal cancers, epidermal growth factor receptor (EGFR) human 2 (Her2) have become efficacious drug targets this setting. But until now, although above studies suggested EGFR Her2 may serve as effective biomarkers for targeted therapy cancer patients with primary tumor, the information on these colorectal is still limited metastases. Objective: The purpose of study to evaluate expression lymph node metastasis (LNM) (CRC), develop LNM- associated CRC. Methods: Differences between CRC LNM (LNM CRC) without (non- were assessed a total 126 Chinese carcinoma samples using quantitative real-time PCR analysis western blot. Confirmation assay immunohistochemistry (IHC) was applied same samples. relationship clinicopathological parameters prognosis candidate also examined Results: significantly upregulated compared non-LNM CRC, which confirmed by polymerase chain reaction, Similar results assay. Overexpression ( P< 0.001), advanced TNM stage increased 5-year recurrence rate 0.001) decreased overall survival 0.001). Univariate multivariate analyses indicated useful independent prognostic 0.05). Conclusions: might potential biomarker Over-expression or predict poor outcome clinical cancer.