Εxpression of enoyl coenzyme a hydratase, short chain, 1, in colorectal cancer and its association with clinicopathological characteristics

摘要: This study aimed to investigate the expression and clinical significance of enoyl coenzyme A hydratase, short chain, 1 (ECHS1), in patients with colorectal cancer (CRC). The ECHS1 protein as detected by immunohistochemistry 148 CRC specimens was evaluated compared pathology prognosis; 38 from proximal non-cancerous tissues were included controls. also measured western blot analysis 46 fresh tissue 22 normal specimens. rate positive differed significantly between (56.76%, 84/148) (5.26%, 2/38) (P<0.001). confirmed not be associated gender or age. However, tended positively TNM stage (P=0.015), lymph node metastasis (P=0.011) histological differentiation (P=0.028). on increased vs. tissues. In addition, overall survival curves estimated Kaplan-Meier method demonstrated that exhibiting low survived longer high levels (P=0.039). Our data suggested may contribute occurrence, progression CRC, is closely prognosis provide useful information for molecular-targeted therapy.