C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma
作者： Futoshi Kawamata , Shigenori Homma , Hirofumi Kamachi , Takahiro Einama , Yasutaka Kato
DOI: 10.1007/S00535-013-0773-6
关键词: Oncology 、 Colorectal cancer 、 Medicine 、 Endothelium 、 Hepatology 、 Lymph node metastasis 、 Lymphovascular invasion 、 Internal medicine 、 Surgical oncology 、 Colorectal adenocarcinoma 、 Mesothelin 、 Gastroenterology
摘要: Background Lymph node metastasis is a key event of colorectal cancer (CRC) progression. Mesothelin expressed in various types malignant tumor and associated with an unfavorable prognosis. The full-length mesothelin (Full-ERC) cleaved by protease into membrane-bound C-ERC/mesothelin N-ERC/mesothelin which secreted the blood. aim this study was to examine biological role CRC clinicopathological analysis vitro lymphatic invasion assay.
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