Preoperative serum levels of mesothelin in patients with colon cancer.

作者: Özgür Bostancı , Özgür Kemik , Ahu Kemik , Muharrem Battal , Uygar Demir

DOI: 10.1155/2014/161954

关键词:

摘要: Background. Screening for biochemical markers is important diagnosing colon cancer. In this study, the reliability of serum mesothelin levels as a potential diagnostic and screening instrument was evaluated concerning Methods. Ninety-five patients who had undergone colonoscopic examination were diagnosed with cancer included in study. The measured ELISA kits terms significant difference when compared between control group. Results. Patients significantly higher than groups. We found associations tumor grade, perineural invasion, vascular invasion (resp., ). Conclusion. Evaluating has to detect screen affected patients. Our data suggest that exhibits effects towards serves biomarker deadly disease.

参考文章(20)
N. Yamaguchi, K. Hattori, M. Oh-eda, T. Kojima, N. Imai, N. Ochi, A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5. Journal of Biological Chemistry. ,vol. 269, pp. 805- 808 ,(1994) , 10.1016/S0021-9258(17)42180-6
Zhanat E Muminova, Theresa V Strong, Denise R Shaw, Characterization of human mesothelin transcripts in ovarian and pancreatic cancer. BMC Cancer. ,vol. 4, pp. 19- 19 ,(2004) , 10.1186/1471-2407-4-19
Ingegerd Hellstrom, John Raycraft, Sandra Kanan, Niranjan Y Sardesai, Thorsten Verch, Yi Yang, Karl Erik Hellstrom, Mesothelin Variant 1 Is Released from Tumor Cells as a Diagnostic Marker Cancer Epidemiology, Biomarkers & Prevention. ,vol. 15, pp. 1014- 1020 ,(2006) , 10.1158/1055-9965.EPI-05-0334
K. Chang, I. Pastan, Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 136- 140 ,(1996) , 10.1073/PNAS.93.1.136
N. Scholler, N. Fu, Y. Yang, Z. Ye, G. E. Goodman, K. E. Hellstrom, I. Hellstrom, SOLUBLE MEMBER(S) OF THE MESOTHELIN/MEGAKARYOCYTE POTENTIATING FACTOR FAMILY ARE DETECTABLE IN SERA FROM PATIENTS WITH OVARIAN CARCINOMA Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 11531- 11536 ,(1999) , 10.1073/PNAS.96.20.11531
Richard G. Moore, Amy K. Brown, M. Craig Miller, Donna Badgwell, Zhen Lu, W. Jeffrey Allard, C.O. Granai, Robert C. Bast, Karen Lu, Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus Gynecologic Oncology. ,vol. 110, pp. 196- 201 ,(2008) , 10.1016/J.YGYNO.2008.04.002
Tetsuo Kojima, Masayoshi Oh-eda, Kunihiro Hattori, Yoshiko Taniguchi, Masahiko Tamura, Norimichi Ochi, Nozomi Yamaguchi, Molecular Cloning and Expression of Megakaryocyte Potentiating Factor cDNA Journal of Biological Chemistry. ,vol. 270, pp. 21984- 21990 ,(1995) , 10.1074/JBC.270.37.21984
N. Tjarda Van Heek, Anirban Maitra, Jens Koopmann, Neil Fedarko, Alka Jain, Ayman Rahman, Christine A. Iacobuzio-Donahue, Volkan Adsay, Raheela Ashfaq, Charles J. Yeo, John L. Cameron, Johan A. Offerhaus, Ralph H. Hruban, Karin D. Berg, Michael Goggins, Gene expression profiling identifies markers of ampullary adenocarcinoma Cancer Biology & Therapy. ,vol. 3, pp. 651- 656 ,(2004) , 10.4161/CBT.3.7.919
Futoshi Kawamata, Shigenori Homma, Hirofumi Kamachi, Takahiro Einama, Yasutaka Kato, Masumi Tsuda, Shinya Tanaka, Masahiro Maeda, Kazunori Kajino, Okio Hino, Norihiko Takahashi, Toshiya Kamiyama, Hiroshi Nishihara, Akinobu Taketomi, Satoru Todo, C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma Journal of Gastroenterology. ,vol. 49, pp. 81- 92 ,(2014) , 10.1007/S00535-013-0773-6
Alfonso Cristaudo, Rudy Foddis, Agnese Vivaldi, Giovanni Guglielmi, Nicola Dipalma, Rosangela Filiberti, Monica Neri, Marcello Ceppi, Michela Paganuzzi, Gian Paolo Ivaldi, Manlio Mencoboni, Pier Aldo Canessa, Nicolino Ambrosino, Antonio Chella, Luciano Mutti, Riccardo Puntoni, Clinical Significance of Serum Mesothelin in Patients with Mesothelioma and Lung Cancer Clinical Cancer Research. ,vol. 13, pp. 5076- 5081 ,(2007) , 10.1158/1078-0432.CCR-07-0629