Emergence of drug-resistance in HIV dynamics under distinct HAART regimes
作者： Ana R.M. Carvalho , Carla M.A. Pinto
DOI: 10.1016/J.CNSNS.2015.06.019
关键词: Disease progression 、 Drug resistance 、 Drug 、 Medicine 、 Virology 、 Hiv patients 、 Human immunodeficiency virus (HIV)
摘要: Abstract In this paper we propose a model for the dynamics of HIV epidemics under distinct HAART regimes, and study emergence drug-resistance. The predicts untreated patients all stages infection. We compute local global stability disease-free equilibrium model. simulate two patients, rapid progressors long-term non-progressors. effects equal RTI PI efficacies, as well drug namely RTI-based PI-based therapeutics. Treatment is initiated when CD 4 + T cells count less than 350 cells mm − 3 . drugs seem to produce better outcomes, with respect disease progression, regimes.
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