Blood dendritic cells: “canary in the coal mine” to predict chronic inflammatory disease?

摘要: The majority of risk factors for chronic inflammatory diseases are unknown. This makes personalized medicine assessment, prognosis, and choice therapy very difficult. It is becoming increasingly clear, however, that low-grade subclinical infections may be an underlying cause many thus contribute to secondary outcomes (e.g. cancer). Many now categorized as inflammatory-mediated stem from a dysregulation in host immunity. There growing need study the links between infections, immune responses they elicit, how this impacts overall health. One such link explored detail here extreme sensitivity myeloid dendritic cells (mDC) peripheral blood role these mDCs play arbitrating resulting responses. We find emerging evidence supports pathogen-induced inflammation leading increased clinical disease. elevated result bacteremia often do not trigger productive response, but can disseminate pathogen throughout host. aberrant trafficking accelerate systemic disease progression. Conversely, restoration DC homeostasis aid elimination minimize dissemination. Thus it would seem prudent when assessing consider mDC numbers, microbial content (microbiome) activation state mDCs. These provide important clues (“the canary coal mine”) high risk. will facilitate development novel immunotherapies eliminate smoldering atherosclerosis, cancer, rheumatoid arthritis, pre-eclampsia.