Vascular Responses to Endothelin-1 in Conscious Rats: Modulation by Endogenous Nitric Oxide
作者： Janos G. Filep , Alain Fournier , Eva Foldes-Filep
DOI: 10.1007/978-1-4615-1903-4_17
关键词: Blood flow 、 Endothelin 1 、 Vascular permeability 、 Nitric oxide 、 Coronary circulation 、 Endocrinology 、 Neutrophil granulocyte 、 Endothelium 、 Evans Blue 、 Internal medicine 、 Chemistry
摘要: The vascular endothelium is an active site for the production of many substances essential in regulation tone and reactivity. For instance, endothelial cells release endothelium-derived relaxing factor (EDRF), now characterized as nitric oxide (NO) (Ignarro et al., 1987; Palmer 1987) endothelin-1 (ET-1) (Yanagisawa 1988). continuous NO from (Ignarro, 1989) appears to play important role intrinsic modulator tone, blood flow microvascular permeability mesenteric (Kubes Granger, 1992) coronary circulation (Filep 1993b).
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