Correlation between cardiorespiratory events and gastro-esophageal reflux in preterm and term infants: Analysis of predisposing factors

摘要: Abstract Background The association between cardiorespiratory events (CRE) and gastro-esophageal reflux (GER) among neonates is still controversial. Aims To test such an in preterm term infants. Study design Prospective observational study. Subjects Forty-seven infants with suspected GER recurrent CRE admitted at a neonatal intensive care unit, who underwent simultaneous synchronized 24-hour recording of heart rate (HR), peripheral oxygen saturation (SpO2) pH-impedance monitoring (MII-pH). HR/SpO2 data were filtered to avoid artefactual episodes hypoxia hypoperfusion. Outcome measures main outcome measure was the symptom probability (SAP), 2-minute time window. Infants positive (>95%) negative (≤95%) SAP index tests compared by univariate multivariate statistics. Results Median gestational age birth 294/7 weeks, median study 36 days. We recorded 3341 4936 (4710 desaturations, 226 bradycardias); 609/4936 (12%) temporally associated episodes: 338 preceded 271 followed events. significant 5/47 (11%) patients. including only following 3/47 (6%). There no difference number acid, weakly non-acid, pH-only preceding or SAP-positive SAP-negative tests. SAP-index those had lower weight gain three days tended have weight. Conclusions