Role of p53 circuitry in tumorigenesis: A brief review.
作者： Sarfaraj Niazi , Madhusudan Purohit , Javed H. Niazi
DOI: 10.1016/J.EJMECH.2018.08.099
关键词: Genome integrity 、 microRNA 、 Genome 、 P53 protein 、 Multicellular organism 、 Normal functioning 、 Chemistry 、 Neuroscience 、 Relevant information 、 Carcinogenesis
摘要: Abstract Maintenance of genome integrity under the stressed condition is paramount for normal functioning cells in multicellular organisms. Cells are programmed to protect their through specialized adaptive mechanisms which will help decide fate conditions. These outcome activation intricate circuitries that regulated by p53 master protein. In this paper, we provided a comprehensive review on p53, homologues and isoforms, including description about ubiquitin-proteasome system emphasizing its role regulation. induced E3(Ub)-ligases an integral part system. This outlines roles important splice variants maintaining cellular protein homeostasis. It also covers up-to-date relevant information small molecule Mdm2 inhibitors originated from different organizations. The ends with discussion future prospects investigation directives development next-generation modulators as therapeutics.
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