Analysis of Somatic Alterations in Cancer Genome: From SNP Arrays to Next Generation Sequencing
作者： Emmanuel Barillot , Valentina Boeva , Elodie Manié , Tatiana Popova , Marc-Henri Stern
DOI:
关键词: Somatic cell 、 Biology 、 Genome 、 DNA sequencing 、 Copy-number variation 、 Allelic Imbalance 、 SNP 、 Allele 、 Genetics 、 Copy number analysis
摘要: In this chapter we consider basic hypothesis, problem statements and technological computa- tional solutions for analysis of copy number alterations in tumor genomes. We provide a data mining tech- nique (based on the GAP method described (Popova et al., 2009)) which allows extraction absolute numbers allelic contents from whole genome variation imbalance profiles obtained by SNP arrays or NGS.
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