Breast milk contains relevant neurotrophic factors and cytokines for enteric nervous system development.
作者： Michael Fichter , Markus Klotz , David L. Hirschberg , Bärbel Waldura , Otto Schofer
关键词: Internal medicine 、 Enteric nervous system 、 Myenteric plexus 、 Neurotrophic factors 、 Ciliary neurotrophic factor 、 Biology 、 Nestin 、 Glial cell line-derived neurotrophic factor 、 Endocrinology 、 Neurite 、 Breast milk
摘要: Breast-feeding plays an important role for the development of newborn. Non-breast fed premature born infants show a significantly higher risk developing diseases like infantile diarrhoea and necrotizing enterocolitis. In this study, content neurotrophic factors cytokines, which might influence postnatal enteric nervous system (ENS), was determined in human breast milk. Glial cell-line-derived factor (GDNF), ciliary (CNTF) as well panel cytokines were analyzed using single or multiplex ELISA. order to link their presence milk with possible effects on ENS, rat myenteric neurons cultured protein extracts from Neurite outgrowth, neuron survival nestin expression glial cells measured. Growth found all samples at varying concentrations. It could be demonstrated that increased amount surviving neurones neurite outgrowth. Additionally it shown, number S100-expressing after incubating extracts. The data suggest milk-born proteins support system.
sci-hub.se 参考文章(26)
Neonatal Necrotizing Enterocolitis, Ann M. Kosloske, Breast milk decreases the risk of neonatal necrotizing enterocolitis. Advances in Nutritional Research. ,vol. 10, pp. 123- 137 ,(2001) , 10.1007/978-1-4615-0661-4_6
J Cambier, E R Jakoi, S Saslow, Transepithelial transport of maternal antibody: purification of IgG receptor from newborn rat intestine. Journal of Immunology. ,vol. 135, pp. 3360- 3364 ,(1985)
Ginny Henderson, Mary Y Anthony, William McGuire, Formula milk versus donor breast milk for feeding preterm or low birth weight infants. Cochrane Database of Systematic Reviews. ,(2007) , 10.1002/14651858.CD002972.PUB2
Ina Tesseur, Kun Zou, Elisabeth Berber, Hui Zhang, Tony Wyss-Coray, Highly sensitive and specific bioassay for measuring bioactive TGF-β BMC Cell Biology. ,vol. 7, pp. 15- 15 ,(2006) , 10.1186/1471-2121-7-15
Karl-Herbert Schafer, Pedro Mestres, Pia Marz, Stefan Rose-John, The IL-6/sIL-6R fusion protein hyper-IL-6 promotes neurite outgrowth and neuron survival in cultured enteric neurons. Journal of Interferon and Cytokine Research. ,vol. 19, pp. 527- 532 ,(1999) , 10.1089/107999099313974
Michael D Gershon, Genes and lineages in the formation of the enteric nervous system Current Opinion in Neurobiology. ,vol. 7, pp. 101- 109 ,(1997) , 10.1016/S0959-4388(97)80127-4
Bo Lönnerdal, Bioactive Proteins in Human Milk: Mechanisms of Action The Journal of Pediatrics. ,vol. 156, pp. S26- S30 ,(2010) , 10.1016/J.JPEDS.2009.11.017
K.-H. Schäfer, Pedro Mestres, The GDNF-induced neurite outgrowth and neuronal survival in dissociated myenteric plexus cultures of the rat small intestine decreases postnatally. Experimental Brain Research. ,vol. 125, pp. 447- 452 ,(1999) , 10.1007/S002210050702
Karl-Herbert Sch�fer, Andrea H�nsgen, Pedro Mestres, Morphological changes of the myenteric plexus during early postnatal development of the rat. Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology. ,vol. 256, pp. 20- 28 ,(1999) , 10.1002/(SICI)1097-0185(19990901)256:1<20::AID-AR4>3.0.CO;2-8
S. Koletzko, P. Sherman, M. Corey, A. Griffiths, C. Smith, Role of infant feeding practices in development of Crohn's disease in childhood. BMJ. ,vol. 298, pp. 1617- 1618 ,(1989) , 10.1136/BMJ.298.6688.1617