Hypertriglyceridemia and regulation of fibrinolytic activity.
作者： L Mussoni , L Mannucci , M Sirtori , M Camera , P Maderna
关键词: Hypertriglyceridemia 、 Plasminogen activator 、 Triglyceride 、 Hepg2 cells 、 Very low-density lipoprotein 、 Antifibrinolytic 、 Plasminogen activator inhibitor-1 、 Internal medicine 、 Medicine 、 Antigen 、 Endocrinology
摘要: A relation between elevated triglyceride (TG) levels and alterations of the fibrinolytic system has been recognized in studies patients with coronary heart disease. In this investigation, total activity specific components were evaluated plasma samples from a highly selected group type IV hyperlipoproteinemia before after dietary treatment aimed at reducing TG levels. The response was comparable to that normolipidemic subjects, whereas tissue-type plasminogen activator antigen venous occlusion (p less than 0.01) resting inhibitor-1 (PAI-1) significantly higher hypertriglyceridemic subjects compared controls. After treatment, 22% reduction attained patients, no appreciable modification parameters. analysis single-patient data revealed tendency toward normalization PAI-1 only those who showed greater or equal 20%. Very low density lipoproteins (VLDLs) both normal concentration-dependently stimulated release by endothelial cells HepG2 cells, effect VLDL being more pronounced on cells. induced competent may thus account for antifibrinolytic protein occur patients.
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