The toxic plant proteins ricin and abrin induce apoptotic changes in mammalian lymphoid tissues and intestine.
作者： Gareth D. Griffiths , Michael D. Leek , D. J. Gee
关键词: Abrin 、 Necrosis 、 Lymphatic system 、 Programmed cell death 、 Cycloheximide 、 Toxin 、 Biology 、 Biochemistry 、 Apoptosis 、 Molecular biology 、 Ricin
摘要: The toxins ricin and abrin are potent inhibitors of protein synthesis. Apoptosis has been shown to be induced in some cells by cycloheximide actinomycin D whereas the process is prevented other same agents, both We were interested find whether caused any apoptotic changes rapidly dividing tissues where we believed that these concentrate. Rats injected intramuscularly with toxin killed at time intervals, being removed examined light electron microscopy. Apoptotic-like bodies abundant para-aortic lymph nodes, Peyer's patches ileal crypts or intoxicated rats. Abrin was found cause markedly more pronounced tissues, when compared a similar dose ricin. Prior this, have reported as causing necrosis animal tissues.
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