Intestinal microbiota and gvhd
作者： Eric G. Pamer , Yusuke Shono , Marcel Van Den Brink , Ying Taur , Robert Jenq
DOI:
关键词: Hematopoietic stem cell 、 Antibiotics 、 Clostridiales 、 Medicine 、 Immunology 、 Endogeny 、 Ruminococcus 、 Eubacterium 、 Nutritional Supplementation 、 Clostridium
摘要: The present disclosure describes compositions and methods for increasing the abundance of commensal bacteria belonging to order Clostridiales , including Blautia, Ruminococcus Clostridium, Eubacterium, Holdemania Dorea species, that are as-sociated with reduced lethal GVHD improved overall survival following bone mar-row or hematopoietic stem cell transplant. disclosure, therefore, provides reducing likelihood, incidence severity by (1) avoiding loss endogenous beneficial species through antibiotic selection; (2) administering a therapeutically effective amount composition comprising one more associated individuals who may lack have lost those strains from their intestinal microbiota. Additionally, support reestablished related as treatment option can also be provided in form nutritional supplementation, example, sugars fermented some activity.
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