Synergistic activity of phenazines isolated from Pseudomonas aeruginosa in combination with azoles against Candida species

摘要: Candidiasis infections are caused by yeasts from the genus Candida. The types of infection range superficial to systemic. Treatment often requires antifungals such as azoles; however, increased use these drugs has led generation with resistance drugs. Here, we describe synergistic anticandidal activity three phenazines—phenazine-1-ol, phenazine-1-carboxylic acid, and phenazine-1-carboxamide. These phenazines were purified Pseudomonas aeruginosa in combination clinically used azoles—fluconazole, itraconazole, clotrimazole. activities azoles assessed using checkerboard microdilution time‐kill methods. Study results show that combined effects predominantly (fractional inhibitory concentration index <0.5). study, which included a minimum azoles, showed growth Candida species was completely attenuated after 0‐6 h treatment. results, suggest may be beneficial, have potential implications delaying development resistance, effect is achieved lower concentrations both agents (phenazines azoles). cytotoxicity also tested against normal human cell line (foreskin fibroblast). No recorded at up 200 µg/ml. vitro reported here for first time.