Outcomes of a Randomized Controlled Trial of Genomic Counseling for Patients Receiving Personalized and Actionable Complex Disease Reports.

摘要: There has been very limited study of patients with chronic disease receiving potentially actionable genomic based results or the utilization genetic counselors in online result delivery process. We conducted a randomized controlled trial on 199 each eight personalized and complex reports online. Primary aims were to assess impact in-person counseling 1) causal attribution risk, 2) personal awareness 3) perceived risk developing particular disease. Of 98 intervention arm participants (mean age = 57.8; 39% female) for counseling, 76 (78%) seen. In contrast, control (n = 101; mean age = 58.5; 54% initially not offered as part protocol but able access if they requested it, 3-months post viewing at least one test report post-completion study-specific follow-up survey. A total 64 59 completed survey measures. found that had enhanced objective understanding variant contribution multiple diseases. Genomic was associated lowered participant beliefs influence across all diseases, compared participants. Our findings also illustrate majority diseases under study, believed knew their status better than subjects. Disease modified during due assessment more comprehensive family history. conclusion, through web portal, common These support development additional interventions ensure high level patient comprehension improve patient-centered health outcomes.