Update on Interconversions of Vitamin B-6 with Its Coenzyme

摘要: Biosynthesis of pyridoxal 5'-phosphate (PLP) depends upon the relatively specific action two consecutive enzymes, viz. (pyridoxine, pyridoxamine) kinase and pyridoxine (pyridoxamine) phosphate oxidase. Less phosphatases catalyze hydrolyses 5'-phosphates vitamers pyridoxal, pyridoxamine, pyridoxine. From recognition a generation ago these processes by which three forms vitamin B-6 their are interconverted, more recent studies have provided fairly sophisticated understanding molecular characteristics enzymes involved. The evolutionary retention homologous portions in humans as well bacteria most finding highly conserved region oxidase, also from both prokaryotic eukaryotic organisms, emphasize importance catalysts formation coenzyme that is essential for organisms. Both oxidase involved metabolism potential targets pharmacologic agents.