Chemokines in the inflammatory bowel diseases.
作者： Richard P. MacDermott
关键词: Ulcerative colitis 、 Intestinal mucosa 、 Chemokine 、 Inflammation 、 Immunology 、 Proinflammatory cytokine 、 Cytokine 、 Inflammatory bowel disease 、 Medicine 、 Crohn's disease
摘要: Ulcerative colitis and Crohn's disease are characterized by chronic intestinal inflammation. Intestinal bacteria initiate the activation of inflammatory processes, which mediated proinflammatory cytokines chemokines. In bowel disease, inflammation is not downregulated, in part due to defective or absent inhibitory processes. Studies date have demonstrated that IL-8, MCP-1, ENA-78 highly expressed mucosa areas active ulcerative colitis. Neutrophils macrophages inflamed intestine synthesize secrete large amounts chemokines patients with disease. Increased chemokine expression has also been observed epithelial cells, endothelial smooth muscle cells. Future trials specific agents capable inhibiting synthesis secretion blocking chemokine-chemokine receptor interaction will be important study
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sci-hub.se 参考文章(47)
L Mazzucchelli, J A Laissue, C Mueller, C Hauser, K Zgraggen, H Wagner, M Hess, Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation. American Journal of Pathology. ,vol. 144, pp. 997- 1007 ,(1994)
Andreas Raedler, William F. Stenson, Richard P. MacDermott, Stefan Schreiber, The Role of the Mucosal Immune System in Inflammatory Bowel Disease Gastroenterology Clinics of North America. ,vol. 21, pp. 451- 502 ,(1992) , 10.1016/S0889-8553(21)00040-6
Chen Ai, Weinstein Mi, Izzo Rs, Hadjiyane C, Pellecchia C, Witkon K, Interleukin-8 and neutrophil markers in colonic mucosa from patients with ulcerative colitis. The American Journal of Gastroenterology. ,vol. 87, pp. 1447- 1452 ,(1992)
Robert D. Fusunyan, Jessica J. Quinn, Mika Fujimoto, Richard P. MacDermott, Ian R. Sanderson, Butyrate switches the pattern of chemokine secretion by intestinal epithelial cells through histone acetylation. Molecular Medicine. ,vol. 5, pp. 631- 640 ,(1999) , 10.1007/BF03402075
Futoshi Arai, Toru Takahashi, Koichi Furukawa, Kouji Matsushima, Hitoshi Asakura, Mucosal Expression of Interleukin-6 and Interleukin-8 Messenger RNA in Ulcerative Colitis and in Crohn's Disease Digestive Diseases and Sciences. ,vol. 43, pp. 2071- 2079 ,(1998) , 10.1023/A:1018815432504
W.E. Pullman, P.J. Sullivan, P.J. Barratt, J. Lising, J.A. Booth, W.F. Doe, Assessment of inflammatory bowel disease activity by technetium 99m phagocyte scanning Gastroenterology. ,vol. 95, pp. 989- 996 ,(1988) , 10.1016/0016-5085(88)90174-6
Robert M. Strieter, Marie D. Burdick, Mark W. Rolfe, Barrett J. Rollins, Robert Paine, Theodore J. Standiford, MCP-1 expression by rat type II alveolar epithelial cells in primary culture. Journal of Immunology. ,vol. 150, pp. 4561- 4570 ,(1993)
Marco Baggiolini, Beatrice Dewald, Bernhard Moser, Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines. Advances in Immunology. ,vol. 55, pp. 97- 179 ,(1994) , 10.1016/S0065-2776(08)60509-X
L Eckmann, M F Kagnoff, J Fierer, Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry Infection and Immunity. ,vol. 61, pp. 4569- 4574 ,(1993) , 10.1128/IAI.61.11.4569-4574.1993
J. Schölmerich, E. Schmidt, C. Schümichen, P. Billmann, H. Schmidt, W. Gerok, Scintigraphic assessment of bowel involvement and disease activity in Crohn's disease using technetium 99m-hexamethyl propylene amine oxine as leukocyte label Gastroenterology. ,vol. 95, pp. 1287- 1293 ,(1988) , 10.1016/0016-5085(88)90363-0