MicroRNAs as Biomarkers and Therapeutic Targets in Melanoma
作者： Daniel W. Mueller , Anja K. Bosserhoff
DOI: 10.1007/978-1-60761-433-3_10
关键词: microRNA 、 Melanoma 、 Multicellular organism 、 Computational biology 、 Biology 、 Structure and function 、 Nematode caenorhabditis elegans 、 Regulation of gene expression 、 Caenorhabditis 、 Biomarker discovery
摘要: MicroRNAs (abbreviated: miRNAs) represent a class of small non-coding RNAs, initially discovered in the nematode Caenorhabditis elegans. In 1993, labs Victor Ambros and Gary Ruvkun cooperatively characterized structure function lin-4, founding member today’s rapidly growing molecule termed microRNAs. However, it was not until year 2000 that Reinhart colleagues detected second miRNA species – let-7. Given sequence let-7 actually conserved large variety Metazoens from Drosophila to humans (in contrast lin-4 which is specific Caenorhabditis), this fueled further research eventually revealed miRNAs are involved posttranscriptional gene regulation virtually all multicellular organisms.
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