Nippostrongylus brasiliensis: infection decreases plasma butyrylcholinesterase activity in rats.
作者： Ayman Samir Farid , Yoichiro Horii
DOI: 10.1016/J.EXPPARA.2009.02.009
关键词: Nippostrongylus brasiliensis 、 Homeostasis 、 Immunology 、 Endocrinology 、 Cholinesterase 、 Aché 、 Biology 、 Internal medicine 、 Butyrylcholinesterase 、 Blood plasma 、 Acetylcholinesterase 、 Toxicity
摘要: Plasma butyrylcholinesterase (BChE) hydrolyzes ester-containing compounds such as succinylcholine, well acting a scavenger against neurotoxic organophosphates (OPs). We previously found that Nippostrongylus brasiliensis infection makes rats more susceptible to OP toxicity by decreasing serum paraoxonase-1 (PON1) activity. In the present study, we examined effects of N.brasiliensis on acetylcholinesterase (AChE) activity in plasma, red blood cells (RBCs), brain and diaphragm, PON1 activity, at day 7 after infection. significantly decreased plasma BChE activities without altering AChE RBCs, diaphragm. These results provide further insight into unusual deleterious intestinal nematode infections body homeostasis.
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