Group D Adenoviruses Infect Primary Central Nervous System Cells More Efficiently than Those from Group C

作者： Miguel Chillon , Assumpció Bosch , Joseph Zabner , Lane Law , Donna Armentano

DOI: 10.1128/JVI.73.3.2537-2540.1999

关键词: Group (periodic table) 、 Gene 、 Serotype 、 Biology 、 Tissue culture 、 Mastadenovirus 、 Cell culture 、 Molecular biology 、 Virology 、 Central nervous system 、 Recombinant DNA

摘要: Group C adenovirus-mediated gene transfer to central nervous system cells is inefficient. We found that wild-type group D viruses, or recombinant adenovirus type 2 (Ad2) (group C) modified contain Ad17 D) fiber, were more efficient in infecting primary cultures of neurons. Together with studies on vascular endothelial and tissue culture cell lines, our results indicate there not a universally applicable serotype for use as vector.

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Group D Adenoviruses Infect Primary Central Nervous System Cells More Efficiently than Those from Group C

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Group D Adenoviruses Infect Primary Central Nervous System Cells More Efficiently than Those from Group C

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