Application of Viral Gene Transfer in Studies of Neurogenic Hypertension

摘要: This chapter reviews the use of viral gene transfer to disentangle complexities neurogenic hypertension. Viral manipulation allows lasting and controllable genetic in selected areas brain different species strains, including experiments spontaneously hypertensive rat, an established model Recent evidence indicates that, contrast pharmacological tools that may act on any cellular target within a given area brain, vectors deliver transgene nonuniform manner, its concentration types cells vary greatly. occurs as result both transductional tropism vector system transciptional activity promoter which are present nucleus. Properties adenoviral lentiviral compared contrasted. Application for overexpression biologically active molecules, expression dominant negative proteins, pathway tracking, other study central mechanisms cardiovascular control discussed. In summary, virally mediated delivery is powerful research tool can be used address wide range questions related human essential