Favipiravir (T-705) inhibits in vitro norovirus replication.
作者： J. Rocha-Pereira , D. Jochmans , K. Dallmeier , P. Leyssen , M.S.J. Nascimento
DOI: 10.1016/J.BBRC.2012.07.034
关键词: Favipiravir 、 Microbiology 、 Murine norovirus 、 Virus 、 Polymerase 、 RNA-dependent RNA polymerase 、 In vitro 、 Norovirus 、 Viral replication 、 Virology 、 Biology
摘要: Human noroviruses are the primary cause of foodborne gastroenteritis. Potent and safe inhibitors needed for treatment/prophylaxis norovirus infections. We demonstrate that Favipiravir [T-705, a drug in advanced clinical development treatment infections with influenza virus] inhibits vitro murine replication. Time-of-drug addition studies reveal T-705 exerts its activity at time-point coincides onset viral RNA synthesis, which is line polymerase as presumed target.
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sci-hub.se 参考文章(22)
Robert L. Atmar, Herbert L. DuPont, Hoonmo L. Koo, Nadim Ajami, Noroviruses: The leading cause of gastroenteritis worldwide. Discovery Medicine. ,vol. 10, pp. 61- 70 ,(2010)
Donald F. Smee, Brian B. Gowen, John D. Morrey, Y. Furuta, M. Wong, K. W. Bailey, K. Jung, Jeffery O. Hall, J. R. Stevens, T-705 Treatment of Late Stage Disease in an Arenaviral Hemorrhagic Fever Model:T-705 Efficacy and Reduced Toxicity Suggests a Viable Alternative to RibavirinTherapy PLOS ONE. ,vol. 3, pp. 3725- ,(2008)
Michele E. Hardy, Norovirus protein structure and function Fems Microbiology Letters. ,vol. 253, pp. 1- 8 ,(2005) , 10.1016/J.FEMSLE.2005.08.031
Kyeong-Ok Chang, Stanislav V. Sosnovtsev, Gaël Belliot, Adriene D. King, Kim Y. Green, Stable expression of a Norwalk virus RNA replicon in a human hepatoma cell line Virology. ,vol. 353, pp. 463- 473 ,(2006) , 10.1016/J.VIROL.2006.06.006
Brian B. Gowen, Donald F. Smee, Min-Hui Wong, Jeffery O. Hall, Kie-Hoon Jung, Kevin W. Bailey, John R. Stevens, Yousuke Furuta, John D. Morrey, Treatment of Late Stage Disease in a Model of Arenaviral Hemorrhagic Fever: T-705 Efficacy and Reduced Toxicity Suggests an Alternative to Ribavirin PLoS ONE. ,vol. 3, pp. e3725- ,(2008) , 10.1371/JOURNAL.PONE.0003725
Marion Koopmans, Progress in understanding norovirus epidemiology. Current Opinion in Infectious Diseases. ,vol. 21, pp. 544- 552 ,(2008) , 10.1097/QCO.0B013E3283108965
Yousuke Furuta, Kazumi Takahashi, Kimiyasu Shiraki, Kenichi Sakamoto, Donald F. Smee, Dale L. Barnard, Brian B. Gowen, Justin G. Julander, John D. Morrey, T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections Antiviral Research. ,vol. 82, pp. 95- 102 ,(2009) , 10.1016/J.ANTIVIRAL.2009.02.198
Brian B. Gowen, Min-Hui Wong, Kie-Hoon Jung, Andrew B. Sanders, Michelle Mendenhall, Kevin W. Bailey, Yousuke Furuta, Robert W. Sidwell, In Vitro and In Vivo Activities of T-705 against Arenavirus and Bunyavirus Infections Antimicrobial Agents and Chemotherapy. ,vol. 51, pp. 3168- 3176 ,(2007) , 10.1128/AAC.00356-07
S. Hansen, S. Stamm-Balderjahn, I. Zuschneid, M. Behnke, H. Rüden, R.-P. Vonberg, P. Gastmeier, Closure of medical departments during nosocomial outbreaks: data from a systematic analysis of the literature. Journal of Hospital Infection. ,vol. 65, pp. 348- 353 ,(2007) , 10.1016/J.JHIN.2006.12.018
Christiane E. Wobus, Larissa B. Thackray, Herbert W. Virgin, Murine Norovirus: a Model System To Study Norovirus Biology and Pathogenesis Journal of Virology. ,vol. 80, pp. 5104- 5112 ,(2006) , 10.1128/JVI.02346-05