Gain of Interaction with IRS1 by p110α-Helical Domain Mutants Is Crucial for Their Oncogenic Functions
作者： Yujun Hao , Chao Wang , Bo Cao , Brett M. Hirsch , Jing Song
DOI: 10.1016/J.CCR.2013.03.021
关键词: Protein kinase domain 、 P110α 、 Protein structure 、 Phosphorylation 、 Cancer research 、 Protein subunit 、 Mutant 、 IRS1 、 Phosphatidylinositol 、 Biology
摘要: … The p110α WT or mutant plasmids were coexpressed with a MYC-tagged IRS1 construct in HEK293 cells for immunoprecipitations. As shown in Figure 1E and Figure S1E, in addition to …
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