Clinical utility of human polymerized hemoglobin as a blood substitute after acute trauma and urgent surgery.

摘要: We have previously documented the safety of 1 unit (50 gram) human polymerized hemoglobin (Poly SFH-P) in healthy volunteers. This report describes first patient trial to assess therapeutic benefit Poly SFH-P acute blood loss. Thirty-nine patients received In = 14), 2 2), 3 15), or 6 8) units instead red cells as part their replacement after trauma and urgent surgery. There were no issues related infusion SFH-P. The plasma concentration ([Hb]) (300 was 4.8 ± 0.8 g/dL (mean SD). Although cell [Hb] fell 2.9 1.2 g/dL, total maintained at 7.5 g/dL. [Hb], despite marked fall due utilization O (extraction ratio) 27 16% from 37 13% Twenty-three (59%) avoided allogeneic transfusions during 24 hours effectively loads unloads maintains lieu loss, thereby reducing transfusions. seems be a clinically useful substitute.