Chronic Gamma-Irradiation Induces a Dose-Rate-Dependent Pro-inflammatory Response and Associated Loss of Function in Human Umbilical Vein Endothelial Cells
作者： T. Ebrahimian , C. Le Gallic , J. Stefani , I. Dublineau , R. Yentrapalli
DOI: 10.1667/RR13732.1
关键词: Radiation protection 、 Cell adhesion molecule 、 Matrigel 、 Inflammatory response 、 Pathology 、 Gamma irradiation 、 Umbilical vein 、 Loss function 、 Pharmacology 、 Dose rate 、 Medicine
摘要: A central question in radiation protection research is dose and dose-rate relationship for radiation-induced cardiovascular diseases. The response of endothelial cells to different low rates may contribute help estimate risks diseases by providing mechanistic understanding. In this study we investigated whether chronic low-dose-rate exposure had an effect on the inflammatory their function. Human umbilical vein (HUVECs) were chronically exposed at a 1.4 mGy/h or 4.1 1, 3, 6 10 weeks. We determined pro-inflammatory profile HUVECs before during exposure, functional consequences measuring capacity form vascular networks matrigel. Expression levels adhesion molecules such as E-selectin, ICAM-1 VCAM-1, release cytokines MCP-1, IL-6 TNF-α analyzed. When t...
harvard.edu
allenpress.com
rrjournal.org
researchgate.net 参考文章(50)
J. Panes, M. A. Perry, D. C. Anderson, A. Manning, B. Leone, G. Cepinskas, C. L. Rosenbloom, M. Miyasaka, P. R. Kvietys, D. N. Granger, Regional differences in constitutive and induced ICAM-1 expression in vivo American Journal of Physiology-heart and Circulatory Physiology. ,vol. 269, ,(1995) , 10.1152/AJPHEART.1995.269.6.H1955
Young-Woong Kim, Xiaoxia Z. West, Tatiana V. Byzova, Inflammation and oxidative stress in angiogenesis and vascular disease Journal of Molecular Medicine. ,vol. 91, pp. 323- 328 ,(2013) , 10.1007/S00109-013-1007-3
Yoshiya Shimada, Hideki Ito, Kazuhiko Kaji, Mitsugu Fukuda, Tumor necrosis factor reduces lifespan of human endothelial cells in vitro Mechanisms of Ageing and Development. ,vol. 55, pp. 245- 254 ,(1990) , 10.1016/0047-6374(90)90152-6
Steven M. Albelda, Endothelial and epithelial cell adhesion molecules American Journal of Respiratory Cell and Molecular Biology. ,vol. 4, pp. 195- 203 ,(1991) , 10.1165/AJRCMB/4.3.195
Douglas M. Noonan, Andrea De Lerma Barbaro, Nicola Vannini, Lorenzo Mortara, Adriana Albini, Inflammation, inflammatory cells and angiogenesis: decisions and indecisions. Cancer and Metastasis Reviews. ,vol. 27, pp. 31- 40 ,(2008) , 10.1007/S10555-007-9108-5
Alexis Donneys, Daniela M. Weiss, Sagar S. Deshpande, Salman Ahsan, Catherine N. Tchanque-Fossuo, Deniz Sarhaddi, Benjamin Levi, Steven A. Goldstein, Steven R. Buchman, Localized deferoxamine injection augments vascularity and improves bony union in pathologic fracture healing after radiotherapy Bone. ,vol. 52, pp. 318- 325 ,(2013) , 10.1016/J.BONE.2012.10.014
Steven Quarmby, Pat Kumar, Shant Kumar, Radiation‐induced normal tissue injury: Role of adhesion molecules in leukocyte–endothelial cell interactions International Journal of Cancer. ,vol. 82, pp. 385- 395 ,(1999) , 10.1002/(SICI)1097-0215(19990730)82:3<385::AID-IJC12>3.0.CO;2-5
Marjan Rafat, Lisa S. Rotenstein, Jennifer L. Hu, Debra T. Auguste, Engineered endothelial cell adhesion via VCAM1 and E-selectin antibody-presenting alginate hydrogels. Acta Biomaterialia. ,vol. 8, pp. 2697- 2703 ,(2012) , 10.1016/J.ACTBIO.2012.04.010
RE Langley, EA Bump, SG Quartuccio, D Medeiros, SJ Braunhut, Radiation-induced apoptosis in microvascular endothelial cells. British Journal of Cancer. ,vol. 75, pp. 666- 672 ,(1997) , 10.1038/BJC.1997.119
Valerie Holler, Valerie Buard, Marie-Helene Gaugler, Olivier Guipaud, Cedric Baudelin, Amandine Sache, Maria del R. Perez, Claire Squiban, Radia Tamarat, Fabien Milliat, Marc Benderitter, Pravastatin Limits Radiation-Induced Vascular Dysfunction in the Skin Journal of Investigative Dermatology. ,vol. 129, pp. 1280- 1291 ,(2009) , 10.1038/JID.2008.360