FGF2 binding, signaling, and angiogenesis are modulated by heparanase in metastatic melanoma cells.
作者： Jane Reiland , Doty Kempf , Madhuchhanda Roy , Yvonne Denkins , Dario Marchetti
DOI: 10.1593/NEO.06244
关键词: Growth factor 、 Cancer research 、 Biology 、 Heparanase 、 Angiogenesis 、 Focal adhesion 、 Signal transduction 、 Fibroblast growth factor receptor 、 MAPK/ERK pathway 、 Heparan sulfate
摘要: … HS act as both low-affinity FGF2 receptors and coreceptors in the formation of high-affinity FGF2 receptors. We have investigated HPSE’s ability to modulate FGF2 activity through HS …
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