On the genetics of sleep disorders: genome-wide association studies and beyond
作者： Michael Parsons
DOI: 10.2147/AGG.S57139
关键词: Genome-wide association study 、 Genetic association 、 Sleep in non-human animals 、 Obstructive sleep apnea 、 Insomnia 、 Medicine 、 Twin study 、 Context (language use) 、 Genetics 、 Narcolepsy 、 Psychiatry
摘要: Sleep is an essential behavior, yet much of its underlying functions are still unknown. The disruption sleep can led to a variety health consequences. Family and twin studies have together shown that genetic factors underlie variation in characteristics disorders. Given the importance our well-being, understanding both prevention treatment these Recently, genome-wide association (GWAS) helped provide evidence associations known novel variants with This review outlines findings from GWAS for number disorders, including insomnia, restless leg syndrome, obstructive apnea, narcolepsy, discusses context supporting independent methodologies. Finally, limitations approaches outlined, along future directions genetics post-GWAS era.
sci-hub.se 参考文章(114)
A genetic risk factor for periodic limb movements in sleep. The New England Journal of Medicine. ,vol. 358, pp. 425- ,(2008) , 10.1056/NEJMC072518
M. Ohayon, Epidemiological study on insomnia in the general population Sleep. ,vol. 19, ,(1996) , 10.1093/SLEEP/19.SUPPL_3.S7
Anselme L. Perrier, Jean Massoulié, Eric Krejci, PRiMA Neuron. ,vol. 33, pp. 275- 285 ,(2002) , 10.1016/S0896-6273(01)00584-0
Michael Deuschle, Michael Schredl, Claudia Schilling, Stefan Wüst, Josef Frank, Stephanie H. Witt, Marcella Rietschel, Magdalena Buckert, Andreas Meyer-Lindenberg, Thomas G. Schulze, Association between a serotonin transporter length polymorphism and primary insomnia. Sleep. ,vol. 33, pp. 343- 347 ,(2010) , 10.1093/SLEEP/33.3.343
Nathaniel F. Watson, Dedra Buchwald, Michael V. Vitiello, Carolyn Noonan, Jack Goldberg, A twin study of sleep duration and body mass index. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. ,vol. 6, pp. 11- 17 ,(2010) , 10.5664/JCSM.27704
Juliane Winkelmann, Thomas C. Wetter, Victor Collado-Seidel, Thomas Gasser, Martin Dichgans, Alexander Yassouridis, Claudia Trenkwalder, Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients. Sleep. ,vol. 23, pp. 597- 602 ,(2000) , 10.1093/SLEEP/23.5.1B
Nathaniel F. Watson, Jack Goldberg, Lester Arguelles, Dedra Buchwald, Genetic and environmental influences on insomnia, daytime sleepiness, and obesity in twins. Sleep. ,vol. 29, pp. 645- 649 ,(2006) , 10.1093/SLEEP/29.5.645
Wayne Hening, Penny Tenzer, John W. Winkelman, Richard P. Allen, Restless legs syndrome: nonpharmacologic and pharmacologic treatments. Geriatrics. ,vol. 62, pp. 13- 16 ,(2007)
Gene Ontology Consortium, None, Gene Ontology Consortium: going forward Nucleic Acids Research. ,vol. 43, ,(2015) , 10.1093/NAR/GKU1179
Christelle Peyron, Juliette Faraco, William Rogers, Beth Ripley, Sebastiaan Overeem, Yves Charnay, Sona Nevsimalova, Michael Aldrich, David Reynolds, Roger Albin, Robin Li, Marcel Hungs, Mario Pedrazzoli, Muralidhara Padigaru, Melanie Kucherlapati, Jun Fan, Richard Maki, Gert Jan Lammers, Constantin Bouras, Raju Kucherlapati, Seiji Nishino, Emmanuel Mignot, None, A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains Nature Medicine. ,vol. 6, pp. 991- 997 ,(2000) , 10.1038/79690