Genetic and environmental influences on insomnia, daytime sleepiness, and obesity in twins.

摘要: STUDY OBJECTIVES To better understand the relationships of insomnia, sleepiness, and obesity. DESIGN Classic twin study. SETTING A community-based registry in Washington State. PATIENTS OR PARTICIPANTS One thousand forty-two monozygotic 828 dizygotic pairs participating University Twin Registry. INTERVENTIONS N/A. MEASUREMENTS AND RESULTS Twins were, on average, 32 years old; 61% were women, 19.5% obese, defined as a body mass index > or = 28. Insomnia sleepiness endorsed by 19.3% 3.7% twins, respectively. correlations higher than twins for insomnia (0.47 versus 0.15), (0.37 0.14), obesity (0.82 0.46). Heritability estimates 57% (p < .001; 95% confidence interval 47-63), 38% .01; 16-46), 73% 49-87). Multivariate genetic model fitting revealed that common additive effects comprised 12.8% phenotypic correlation between .01) 10% .01). The was not due to effects. CONCLUSIONS Insomnia, are under strong influence. Common observed both obesity, suggesting shared contributions these phenomena.