Brain changes in dementia of Alzheimer's type relevant to new imaging diagnostic methods.

摘要: The aim of the article is to correlate grey and white matter changes their topography results modern methods for brain imaging such as CT, rCBF, PET, SPECT NMR in Alzheimer's type dementia. findings are based on study a large material investigated thoroughly patho-anatomically. correlated with psychiatric neurophysiologic follow-up studies. degenerative process shows regionally varying accent according pattern which consistent typical disease. This corresponds metabolic PET thereby becomes diagnostic value. largely symmetric. Metabolic asymmetries have however been reported scans. In this context individual variations topographic normal anatomical interest. also frequently changes, particular loss myelin axons mild gliosis, slight 1/3 cases severe an additional 1/3. These cause decrease density centrum semiovale correlating lipid depletion. They may influence ventricular shape size, interest CT or Also here shape, due pathological processes unrelated Alzheimer disease, confusion, regarding degree atrophy even process. Such factors should be considered interpretation non-invasive