beta-Carotene and alpha-tocopherol inhibit the development of atherosclerotic lesions in hypercholesterolemic rabbits.

摘要: Male New Zealand White rabbits were made hypercholesterolemic by feeding an atherogenic diet (0.5% cholesterol, 3% peanut oil, and coconut oil) with or without (control) antioxidants for 8 weeks. The antioxidant treatments intravenous injection of beta-carotene (25 mg/kg/BW, twice weekly), dietary supplementation alpha-tocopherol (0.5%), a combination both. Antioxidant significantly increased plasma LDL levels in the above three groups. Intravenous decreased total cholesterol concentrations, thoracic atherosclerotic lesion area, intimal thickness, but had no effects on oxidation ex vivo as compared to control. Added susceptibility vivo, aortic area Combination both well thickness at arch aorta control, not These data suggest that antihypercholesterolemic may benefit fed inhibiting development lesions.