Complexes formed in vivo between immunoglobulin light chain κ, prealbumin, and/or α1-antitrypsin in myeloma sera

作者: Carl-Bertil Laurell

DOI: 10.1016/0019-2791(70)90228-4

关键词: Blood proteinsα1 antitrypsinBiochemistryProteinuriaChemistryTransthyretinImmunoglobulin light chainIn vivo

摘要: Abstract Complexes between κ chains and plasma proteins were regularly found in sera from patients with Bence-Jones proteinuria of type but not λ. These complexes are preferentially formed prealbumin α 1 -antitrypsin. They split by mercaptoethanol.

参考文章(6)
A. Solomon, J. Killander, H. M. Grey, H. G. Kunkel, Low-Molecular-Weight Proteins Related to Bence Jones Proteins in Multiple Myeloma Science. ,vol. 151, pp. 1237- 1239 ,(1966) , 10.1126/SCIENCE.151.3715.1237
N. Heimburger, K. Heide, H. Haupt, H.E. Schultze, Bausteinanalysen von humanserumproteinen Clinica Chimica Acta. ,vol. 10, pp. 293- 307 ,(1964) , 10.1016/0009-8981(64)90059-2
C.-B. Laurell, ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS. Analytical Biochemistry. ,vol. 10, pp. 358- 361 ,(1965) , 10.1016/0003-2697(65)90278-2
J. A. Gally, G. M. Edelman, PROTEIN-PROTEIN INTERACTIONS AMONG L POLYPEPTIDE CHAINS OF BENCE-JONES PROTEINS AND HUMAN γ-GLOBULINS Journal of Experimental Medicine. ,vol. 119, pp. 817- 836 ,(1964) , 10.1084/JEM.119.5.817
H. G. M. Clarke, T. Freeman, Quantitative immunoelectrophoresis of human serum proteins. Clinical Science. ,vol. 35, pp. 403- 413 ,(1968)