HIV-2 capsids distinguish high and low virus load patients in a West African community cohort.
作者： Clayton O. Onyango , Aleksandra Leligdowicz , Masaru Yokoyama , Hironori Sato , Haihan Song
DOI: 10.1016/J.VACCINE.2009.08.060
关键词: Cohort 、 Acquired immunodeficiency syndrome (AIDS) 、 Virus 、 Viral load 、 Immunology 、 Capsid 、 Lentivirus 、 Virulence 、 Viral replication 、 Virology 、 Biology
摘要: HIV-2 causes AIDS similar to HIV-1, however a considerable proportion of infected patients show no disease and have low plasma virus load (VL). An analysis capsid (p26) variation demonstrated that proline at p26 positions 119, 159 178 are more frequent in lower VL subjects while non-proline residues all three sites with high VL. In vitro replication levels viruses bearing changes the suggested these influence by altering susceptibility TRIM5α. These results provide new insights into pathogenesis.
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