Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.
作者： Burcu F. Darst , Rebecca L. Koscik , Annie M. Racine , Jennifer M. Oh , Rachel A. Krause
DOI: 10.3233/JAD-160195
关键词: Alzheimer's disease 、 Internal medicine 、 Amyloid beta 、 Neuroscience 、 Psychology 、 Pittsburgh compound B 、 Amyloid 、 Genome-wide association study 、 Neurodegeneration 、 Dementia 、 Apolipoprotein E 、 Oncology
摘要: Polygenic risk scores (PRSs) have been used to combine the effects of variants with small effects identified by genome-wide association studies. We explore the potential for using …
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