RNA Expression of Breast Cancer Resistance Protein, Lung Resistance-related Protein, Multidrug Resistance-associated Proteins 1 and 2, and Multidrug Resistance Gene 1 in Breast Cancer: Correlation with Chemotherapeutic Response

摘要: Purpose: The aim of this study was to investigate whether expression particular drug resistance genes in primary operable breast cancer correlates with response first-line chemotherapy advanced disease. Experimental Design: We determined mRNA levels BCRP , LRP MRP1 MRP2 and MDR1 59 tumor specimens patients who received as systemic treatment after diagnosis disease. relative were measured by quantitative real-time reverse transcription-PCR subsequently analyzed relation the type chemotherapy, length progression-free survival (PFS), post-relapse overall survival. Results: For each these genes, a large variation level observed among tumors different patients. When analyzing response, it found that median five responding tumors, compared nonresponding markedly lower. Classification high versus low respect showed MDR1-high subset (17%), MDR1-low (68%), significantly lower ( P = 0.005). Although similar differences rate for subsets stratified other none statistically significant. However, subgroup treated anthracycline-based (5-fluorouracil, Adriamycin/epirubicin, cyclophosphamide), correlation between (only PFS) found, whereas such an association not present cyclophosphamide, methotrexate, 5-fluorouracil-treated group Furthermore, well be associated poor PFS 0.04 < 0.001, respectively). lung resistance-related protein, limited 5-fluorouracil, cyclophosphamide. Expression or related PFS. no found. Conclusions: In pilot study, inversely efficacy significant predictor prognosis Apart from might have some additional predictive value clinical outcome.