Clinical Relevance of Multidrug-Resistance-Proteins (MRPs) for Anticancer Drug Resistance and Prognosis

摘要: Chemoresistance in cancer is frequently associated with elevated levels of multidrug transporters. While P-glycoprotein the best known, majority transporters belong to Multidrug Resistance Protein (MRP) family, also known as ABCC which includes MRP1–9. These proteins are typically found plasma membrane cells, where they efflux a broad range both physiological substrates and xenobiotics, including anticancer drugs. Consistent removal chemotherapeutics from cell, high expression several MRPs has been linked poorer outcome variety types, suggesting these represent targets for therapy. In this review we will describe reported MRP1–9 vitro, discuss associations between MRP family patient outcome, investigate evidence that members contribute directly drug resistance based on vivo models data. We value prognostic marker its potential role selecting treatment protocols examine existing novel strategies target MRPs.