EVIDENCE FOR INHIBITORY COMPLEXES FORMED WITH CYTOCHROME P-450 AND A METABOLITE OF 1,1-DISUBSTITUTED HYDRAZINES
作者： R.N. Hines , R.A. Prough
DOI: 10.1016/B978-0-12-187702-6.50117-1
关键词: Cytochrome c peroxidase 、 Stereochemistry 、 Coenzyme Q – cytochrome c reductase 、 CYP1A2 、 Cytochrome P450 reductase 、 Cytochrome C1 、 Cytochrome 、 Chemistry 、 Cytochrome c 、 Cytochrome c oxidase
摘要: Publisher Summary Hydrazine and its derivatives are used in industry medicine because of their chemical reactivity. These compounds have also been shown to be toxic and/or carcinogenic agents. This chapter describes the biochemical nature a cytochrome P-450 spectral intermediate when any number 1, 1–disubstituted hydrazines were added suspensions rat liver microsomes presence nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) oxygen. The provides evidence that complex is abortive and, thus, complexed can no longer function role as terminal oxidase. In NADPH oxygen, metabolized products form with P-450. metabolite stabilized ferric state reduction ferrous was only seen under anaerobic conditions reversed by re-addition Studies known substrates inhibitors induction experiments suggest formation dependent on metabolism phenobarbital-induced
sci-hub.st 参考文章(6)
Bela Toth, Synthetic and Naturally Occurring Hydrazines as Possible Cancer Causative Agents Cancer Research. ,vol. 35, pp. 3693- 3697 ,(1975)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
T. Nash, The colorimetric estimation of formaldehyde by means of the Hantzsch reaction Biochemical Journal. ,vol. 55, pp. 416- 421 ,(1953) , 10.1042/BJ0550416
Tsuneo Omura, Ryo Sato, The Carbon Monoxide-binding Pigment of Liver Microsomes Journal of Biological Chemistry. ,vol. 239, pp. 2370- 2378 ,(1964) , 10.1016/S0021-9258(20)82244-3
Russell A. Prough, Daniel M. Ziegler, The relative participation of liver microsomal amine oxidase and cytochrome P-450 in N-demethylation reactions Archives of Biochemistry and Biophysics. ,vol. 180, pp. 363- 373 ,(1977) , 10.1016/0003-9861(77)90050-9
E. L. Isaacson, B. S S Masters, H. R. Adams, Inhibition of hepatic microsomal enzymes by chloramphenicol. Journal of Pharmacology and Experimental Therapeutics. ,vol. 203, pp. 388- 396 ,(1977)