Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and Minions.
作者： Salvatore Giovanni Vitale , Antonio Simone Laganà , Angela Nigro , Valentina Lucia La Rosa , Paola Rossetti
DOI: 10.1155/2016/6517313
关键词: Obesity 、 Type 2 Diabetes Mellitus 、 Peroxisome proliferator-activated receptor 、 Biology 、 Receptor 、 Internal medicine 、 Endocrinology 、 Bioinformatics 、 Narrative review
摘要: The prevalence of obesity and metabolic diseases (such as type 2 diabetes mellitus, dyslipidaemia, cardiovascular diseases) has increased in the last decade, both industrialized developing countries. This also coincided with our observation a similar increase cancers. aetiology these is very complex involves genetic, nutritional, environmental factors. Much evidence indicates central role undertaken by peroxisome proliferator-activated receptors (PPARs) development disorders. Due to fact that their ligands could become crucial future target-therapies, PPARs have therefore focal point much research. Based on this evidence, narrative review was written purpose outlining effects PPARs, actions, prospective uses
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