Cancer Cell Expression of Autotaxin Controls Bone Metastasis Formation in Mouse through Lysophosphatidic Acid-Dependent Activation of Osteoclasts

作者: Marion David , Estelle Wannecq , Françoise Descotes , Silvia Jansen , Blandine Deux

DOI: 10.1371/JOURNAL.PONE.0009741

关键词: Bone metastasisBone resorptionBreast cancerAutotaxinPathologyCancer cellMetastasisLysophosphatidic acidCarcinomaChemistryGeneral Biochemistry, Genetics and Molecular BiologyGeneral Agricultural and Biological SciencesGeneral Medicine

摘要: … conditioned media or recombinant autotaxin enhanced M-CSF/RANK-L induced differentiation of … Bone metastasis experiments using 4T1 cells and transfectants were performed using …

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