Cancer as a Complex Developmental Disorder—Nineteenth Cornelius P. Rhoads Memorial Award Lecture

摘要: Abstract The processes of differentiation and tumorigenesis have been long thought to be connected. recent identification Patched , a gene essential for Drosophila embryonic development, as tumor suppressor has focused attention on the concept that involves abnormalities development. In fact, large number genes in signalling pathway are either suppressors or oncogenes. This supports growth control is critical requirement differentiation, aberrant cellular development can contribute malignancy. Whereas result dominantly inherited cancer syndromes played vital role understanding cancer, vast majority “sporadic” cancers properties complex genetic disease. Approaches identify common alleles cancer-associated promise increase our disease aid rational design preventative therapeutic strategies.