Adjuvant treatments following curative resection for gastric cancer
作者： , G. Bonfanti
关键词: Aplasia 、 Cancer 、 Adjuvant 、 Prognostic variable 、 Randomized controlled trial 、 Medicine 、 Chemotherapy 、 Surgery 、 Adjuvant therapy 、 Levamisole
摘要: The results of a prospective randomized trial adjuvant treatment after curative resection for gastric cancer are reported. study consisted three arms: (1) surgery only; (2) chemotherapy (5-fluoro-uracil (FU) and 1-(2-chloroethyl)-3-(4-methylcyclohexil)-1-nitrosourea (Me-CCNU)) surgery; (3) chemo-immunotherapy (FU, Me-CCNU levamisole) surgery. Between March 1977 June 1981, 235 patients were included in the by 18 co-operating institutions. Thirteen per cent arm 2 thirteen 3 suffered major toxicity, necessitating interruption treatment. Two these died marrow aplasia. Statistical analysis survival showed that prognosis was influenced well-known prognostic variables, invasion wall, nodal status site tumour. different treatments arms, however, did not show any impact on prognosis, even when adjustments made most relevant variables. Given lack effect presence clinically important FU ± levamisole cannot be recommended as therapy resected cancer.
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