Postoperative chemo‐radiotherapy versus chemotherapy for resected gastric cancer: A systematic review and meta‐analysis

摘要: Introduction This study conducted a systematic review and meta-analysis (direct indirect) of published randomised controlled trials (RCTs) to compare the effects postoperative chemo-radiotherapy (ChRT) with chemotherapy (Ch) on overall disease-free survival (DFS) for patients resectable gastric cancer. Methods We searched MEDLINE CENTRAL from date inception annual meeting proceedings American Society Clinical Oncology Radiation 1999 November 2012 RCTs comparing ChRT Ch, surgery alone Ch alone. The primary outcome was (OS); secondary outcomes included DFS toxicity. Hazard ratios (HRs), confidence intervals (CIs) P values (P) were estimated fixed models using Revman 5.1. Results We found six (n = 1171). Meta-analysis direct comparison showed that significantly improved both OS (HR 0.80, 95% CI 0.65–0.98, P = 0.03) 0.76, 0.63–0.91, P = 0.003) when compared Ch. There no significant differences in toxicity between two groups. Conclusions This suggests benefit over resected cancer.