ADJUVANT CHEMOTHERAPY IN OPERABLE GASTRIC CANCER: 5 Year Follow-up of First British Stomach Cancer Group Trial
作者： WilliamH. Allum , MichaelT. Hallissey , KrystynaA. Kelly , British Stomach Cancer Group
DOI: 10.1016/S0140-6736(89)91607-3
关键词:
摘要: 411 patients were entered into a prospective, randomised controlled trial of adjuvant chemotherapy after gastrectomy for adenocarcinoma. After follow-up at least 5 1/2 years there has been no survival advantage those receiving 5-fluorouracil and mitomycin C with or without an induction course 5-fluorouracil, vincristine, cyclophosphamide, methotrexate compared undergoing surgery only. There have 366 deaths, including 22 from treatment-related conditions. A multivariate analysis prognostic factors demonstrated that stage disease, nodal resection margin involvement, the presence residual disease are significant determinants survival. Weight loss before had independent influence on The combination preoperative symptoms intraoperative findings may be used to select radical palliative procedures.
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