Quorum sensing of bacteria and trans-kingdom interactions of N-acyl homoserine lactones with eukaryotes.

摘要: Many environmental and interactive important traits of bacteria, such as antibiotic, siderophore or exoenzyme (like cellulose, pectinase) production, virulence factors pathogens, well symbiotic interactions, are regulated in a population density-dependent manner by using small signaling molecules. This phenomenon, called quorum sensing (QS), is widespread among bacteria. different bacterial species communicating “speaking” through diffusible The production often sophisticatedly via an autoinducing mechanism. A good example the N-acyl homoserine lactones (AHL), which occur many variations molecular structure wide variety Gram-negative In Gram-positive other compounds, peptides, regulate cellular activity behavior cell density. degradation molecule—called quenching—is probably another integral part complex circuit. Most interestingly, molecules also recognized eukaryotes that colonized QS-active this case, cross-kingdom interaction can lead to specific adjustment physiological adaptations eukaryote. responses manifold, modifications defense system, modulation immune response, changes hormonal status growth responses. Thus, with bacteria profoundly change physiology higher organisms too. Higher obligatorily associated microbial communities, these truly multi-organismic consortia, holobionts, actually be steered multiple interlinked substances originate not only from host but