Endothelin-1 induces expression of fetal genes through the interleukin-6 family of cytokines in cardiac myocytes.
作者： Shuichi Saito , Ryuichi Aikawa , Ichiro Shiojima , Ryozo Nagai , Yoshio Yazaki
DOI: 10.1016/S0014-5793(99)00936-9
关键词: NPR2 、 Tyrosine kinase 、 Glycoprotein 130 、 Molecular biology 、 Protein kinase C 、 Atrial natriuretic peptide 、 Chemistry 、 Endothelin 1 、 Myocyte 、 Leukemia inhibitory factor
摘要: Abstract We here examined the role of interleukin-6 (IL-6) family cytokines in endothelin-1 (ET-1)-induced hypertrophic responses using cultured cardiac myocytes neonatal rats. ET-1 induced expression IL-6 and leukemia inhibitory factor (LIF) genes. ET-1-induced LIF gene was abolished by inhibition protein kinase C activity. activated promoter atrial natriuretic peptide β-type myosin heavy chain genes through tyrosine pathway receptor gp130. These results suggest that mediates some fetal myocytes.
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