ANP expression in the hypertensive heart.

摘要: Atrial natriuretic peptide (ANP), the principal member of factor family peptides, primarily a product atria in adult heart, is also expressed fetal ventricles. A minority ventricular impulse-conducting cells and myocytes exposed to extreme tension retain capacity produce ANP adult. The number distribution ANP-expressing increases dramatically when ventricle pressure loaded hypertrophied, as case chronic hypertension. Coregulation hypertrophy expression has established this marker myocardial activation gene program, typical condition. However, coordinated reduction hypertension while persists indicates that hemodynamic state overrules controlling hypertensive rat hearts. Under these circumstances, reduced activity cardiac-restricted transcription GATA-4 (a regulator both expression) correlated with downregulation but not hypertrophy, which remained unchanged. Therefore, maintenance cardiac essential may be dependent solely on GATA activity: it seems additional factors involved. It suggested cell size production are autonomous features myocyte heart and, although governed by similar mechanisms, two manifested independently.